131 – Mitogenic Effect of Several Interleukins, Neuromediators and Hormones on Human Glioblastoma Cells, and its Inhibition by the Selective Anticancer Agent PB-100

Deutsche Zeitschrift für Onkologie, 28, 1, 1996, pp. 14-22 Available in English only ABSTRACT: We investigated in vitro the effect of six different substances present in the brain on two human cell lines: U251-BCNU-resistant glioblastoma cells, derived from a highly malignant cerebral tumor, and, as their normal counterparts, CRL 1656 astrocytes. The cytokines IL-4 and IL-10 (alone or together with IL-6), the catecholamine neuromediators dopamine and epinephrine, the steroid hormones progesterone and testosterone all significantly stimulated multiplication of the glioblastoma cells, but enhanced to a much lesses extent multiplication of normal astrocytes. The selective anticancer agent PB-100* inhibited these stimulatory effects. In addition, it could dose-dependently kill over 98% of the malignant cells while not affecting normal cells.Voir le document